DESCRIPTION (provided by applicant): Human health has benefited tremendously from the therapeutic application of monoclonal antibodies (mAb), treating painful and. Pakistan Affairs Books.

Epitope-based vaccines (EVs) have recently been attracting significant interest. They trigger an immune response by confronting the immune system with immunogenic peptides derived from, e.g. Viral- or cancer-related proteins. Binding of these peptides to proteins from the major histocompatibility complex (MHC) is crucial for immune system activation. However, since the MHC is highly polymorphic, different patients typically bind different repertoires of peptides. Furthermore, economical and regulatory issues impose strong limitations on the number of peptides that can be included in an EV.

Hence, it is crucial to identify the optimal set of peptides for a vaccine, given constraints such as MHC allele probabilities in the target population, peptide mutation rates and maximum number of selected peptides. Source text: (Toussaint and Kohlbacher, 2009). Nucleic Acids Res. See more expand_more See less expand_less.

DNASTAR's offers the application, which includes epitope prediction methods that allow you to predict B-cell epitopes based on protein sequence data. You can then view predicted epitopes and antigenic regions along your sequence and structure and compare predictions to other characteristics, such as surface probability. Protean 3D also allows you to: • Create molecular and solvent accessible surfaces around your structure and view predicted epitopes relative to the protein surface • View confidence scores for predicted antigenic regions • Change appearance of predicted epitopes on the sequence and structure for optimized visualization.